Complex Disorders Alliance

For many patients, chronic illness begins with an infection that never seems to fully resolve. At CODA, we are studying how viral persistence, latent viral reactivation, and microbial disruption may contribute to ongoing immune activation and chronic symptoms after an acute infection has passed.

Viral and Microbial Persistence is one of five interconnected research domains within CODA’s Neuroimmune Research Portfolio. Together, these domains investigate the biological mechanisms underlying complex chronic disorders across diagnostic categories.

CODA is funding research to better understand how persistent viral antigens, reactivated latent viruses, microbiome disruption, and chronic immune engagement may contribute to long-term illness. This work investigates biological mechanisms that have been implicated in conditions such as Long COVID, ME/CFS, and related disorders.

Swipe to learn more about the science and the studies behind this work.
🔗 https://hubs.ly/Q04kxccd0

Advancing the deep understanding of complex chronic disorders begins with understanding how the body's systems work together.

By supporting research across interconnected domains - including neuroimmune signaling, immune network dysfunction, vascular biology, autonomic regulation, and structural health - CODA is helping advance the scientific knowledge needed to inform future diagnostics and treatments available to patients.

These studies are designed to generate evidence that advances scientific understanding and helps inform better treatments for individuals living with Long COVID, ME/CFS, POTS/dysautonomia, craniocervical dysfunction, and related complex chronic conditions.

Every donation helps accelerate discovery, support scientific collaboration, and move promising research forward.

Help fund research that sees the whole patient.
🔗 https://hubs.la/Q04khxqQ0

The immune system is designed to activate in response to a threat and then return to balance. At CODA, we are studying what happens when the mechanisms that regulate that process stop functioning properly.

Immune Network Dysregulation is one of five interconnected research domains within CODA’s Neuroimmune Research Portfolio. Together, these domains investigate the biological mechanisms underlying complex chronic illness across diagnostic categories.

CODA is funding research to better understand immune dysregulation, including how immune pathways become activated, suppressed, misdirected, or unable to return to balance in complex chronic illness. This work investigates how disruptions in immune regulation may contribute to persistent inflammation, hypersensitivity, and multisystem symptoms across patient populations.

Swipe to learn more about the science and the studies behind this work.
🔗 https://hubs.la/Q04jVD1r0

For many patients living with EDS and complex chronic conditions, survival becomes the baseline.

Daily life is shaped by symptoms, limitations, and uncertainty. Even with a diagnosis, patients are often left without clear or effective treatment pathways.

This reflects a fundamental gap in how these conditions are studied.

Progress depends on research that connects biological systems, identifies underlying mechanisms, and translates that understanding into more precise treatment approaches.
At CODA, this is the focus of our work.

Advancing this research requires sustained investment.
Support the science patients are waiting for: https://www.complexdisorders.org/research-programs

At CODA, we believe every patient deserves answers. That starts with understanding the biology contributing to their symptoms.

CODA's Neuroimmune Research Portfolio is built around five interconnected research domains that study complex chronic illness as a whole, not by a single diagnosis.

CODA is funding research to better understand how disrupted communication between the nervous system and immune system may drive chronic illness and persistent symptoms. This work explores how targeted treatments may help restore healthier signaling and improve symptoms for a certain subgroup of patients.

Swipe to learn more about the science and the studies behind this work.
🔗 https://hubs.la/Q04jcycl0

Every person living with ME/CFS, Long COVID, POTS, EDS, MCAS, and/or other complex, chronic disorders deserves a research strategy that matches the needs of their biology.

That's exactly what CODA is building: multisystem research for multisystem conditions.

Our research is organized around five core neuroimmune domains, the interconnected biological systems most consistently involved in complex chronic disease. Together, they form a scientific framework built to do what medicine has yet to deliver for this community: subtype patients by biology and match the right treatment to the right person at the right time.

Neuroimmune Signaling Immune Network Dysregulation Viral & Microbial Persistence CSF, Glymphatics, Cerebral & Venous Blood Flow Structural Mechanics & Instability

Progress is possible. This is how we get there. This research framework drives every study and initiative CODA funds.

Visit the link in our bio to learn more about CODA's Neuroimmune Research Portfolio.

CODA is proud to announce its 2026 Research Portfolio!

This marks a significant step forward in how we approach complex chronic disease. Our work is grounded in a systems-level model that studies the full patient and connects the biology that may drive these conditions.

This approach brings together leading scientists, emerging technologies, and coordinated research efforts across neuroimmune systems to move toward more precise and effective treatment.

Progress begins with understanding.

Visit https://hubs.la/Q04hS-7v0 to learn more.

Erica’s story reflects the reality many patients face.

Answers can take years to find. Even with a diagnosis, the path to effective treatment is often unclear.

Research is how we change that.

At CODA, we study the full patient to better understand what is driving disease across systems. That understanding leads to more precise, effective treatment options.

There is a path forward and it starts with science.

Support research that leads to better treatments for the millions of patients like Erica: www.complexdisorders.org

Why does microvascular research matter for patients living with complex chronic disorders?

New research led by Professor Resia Pretorius at Stellenbosch University, in collaboration with Dr. Michal “Mikki” Tal at Massachusetts Institute of Technology (MIT), is advancing the study of microvascular function in conditions such as ME/CFS and Long COVID.

This work expands the ability to observe and analyze microvascular systems and can strengthen the understanding of how these processes contribute to disease at a systems level.

These insights are helping inform the development of more precise diagnostic frameworks and targeted therapeutic approaches for patients.

CODA is committed to supporting research that unites best-in-class science and accelerates progress toward improved patient outcomes.

Explore how this research is advancing the field: https://hubs.la/Q04gSpst0