Jeff's Topcare Pharmacy

Why do we make sub-lingual Tirzepatide and Semaglutides verses oral tablets...Sublingual administration offers faster, more direct absorption than oral ingestion because it bypasses digestive enzymes and liver metabolism ("first-pass effect"), allowing drugs to enter the bloodstream directly through sublingual mucosa capillaries. It provides a rapid onset of action, often acting within minutes, making it ideal for emergencies, patients with swallowing difficulties, or drugs degraded by stomach acid.
National Center for Biotechnology Information (.gov)
National Center for Biotechnology Information (.gov)
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Key Advantages of Sublingual vs. Oral Administration
Faster Onset of Action: Sublingual drugs dissolve under the tongue and enter the bloodstream immediately, making them highly effective for rapid therapeutic relief (e.g., nitroglycerin for chest pain) compared to waiting for digestion.
Avoids First-Pass Metabolism: Sublingual drugs bypass the liver's extensive breakdown, ensuring that a higher percentage of the active dose enters circulation, often requiring lower, more efficient dosages.
Protection from Gastric Degradation: The drug is not exposed to harsh stomach acids or intestinal bile, which can break down many medications before they work.
Improved Patient Compliance: Ideal for individuals who have difficulty swallowing pills (dysphagia), are nauseous, or are vomiting.
Minimal Interaction with Food: Since the drug is absorbed through the mouth's mucous membrane, it is not affected by what is in the patient's stomach

We are now compounding sub-lingual Tirzepatide. Since it is dissolved in mouth and enters the blood stream this process helps it work extremely well.

The tablet version of Tirzepatide is not as effective as they go through the liver and a lot of the active drug in Tirzepatide is destroyed before it can enter the blood stream.

We have seen customers using the sub-lingual Tirzepatide achieve similar results as the injectable version.

The sub-lingual dose has to be taken daily instead of once a week as the injectable but it is a lot more affordable

Call us for details and prices and let it help you achieve your weight loss goals.

People have asked me a few questions about Paxlovid to treat COVID, and I thought I’ll share a few things with you

Paxlovid must be started within FIVE days of start of being tested for positive results for COVID

You take three Paxlovid pills twice daily for five days for a full course that adds up to 30 pills. It helps that the pills are packaged in a “dose card,” basically a medication blister pack that allows you to punch out the pills as needed.

It’s important to note that although health care providers can write a prescription, pharmacists may also provide Paxlovid (with certain limitations) if they’ve opted to do so, provided you can share your electronic or printed medical records, including a list of medications you are already taking, and blood test results from the last 12 months.

Side effects associated with taking PAXLOVID

an altered or impaired sense of taste
diarrhea
increased blood pressure
muscle aches
abdominal pain
nausea
feeling generally unwell
Since Paxlovid is cleared by the kidneys, dose adjustments may be required for patients with mild-to-moderate kidney disease

Avoid taking statin drugs while you are on Paxlovid

The list of drugs that Paxlovid interacts with includes some organ anti-rejection drugs that transplant patients take, as well as more common drugs like some used to treat heart arrhythmias. Paxlovid also decreases the metabolism of anticoagulants, or blood thinners, that many older adults depend on, driving up levels of those medications in the body to a point where they are unsafe, Dr. Topal explains.
It also interacts with cholesterol-lowering medications like Lipitor, but that’s less challenging for patients to overcome. “If you stop taking your Lipitor for five days, nothing bad is going to happen,” he adds.

We are always available at the pharmacy to answer your questions and help you get well and stay well. Call us or visit us anytime. Stay safe.