Yadav Lab at UW

We are excited to share the agenda for the Second Annual TAOK1 Rare Disease Day. For those that would like to attend please register here: https://forms.gle/LWrjPXNmLgdJnrXY6

More information can be found on our lab website https://yadavlab.com/taok1-research-day/

We look forward to sharing research from the Yadav Lab and how to get involved with TAOK1 research.

We are excited to announce the 2nd annual TAOK1 Rare Disease Day Virtual Symposium! This symposium will bring together families and researchers to discuss current TAOK1 research, therapeutic avenues and how to support TAOK1 research.

The virtual symposium will be on April 9th at 3pm PDT (10pm UTC) and on April 10th at 10am PDT (5pm UTC). You can register to attend using the QR Code or this link: https://forms.gle/LWrjPXNmLgdJnrXY6

We will be posting more details here and on our lab website https://yadavlab.com/ .

New study expands the TAOK1/TAOK2 story: TAOK1 variants linked to neurodevelopmental disorders, macrocephaly, & hypotonia, while TAOK2 brings autism, obesity. 30+ novel variants ID’d—highlighting the kinase domain as a hotspot https://bit.ly/4ilZCr6

We are excited to share the agenda for the First Annual TAOK1 Rare Disease Day. For those that would like to attend please register here: https://forms.gle/MDGqXc6CD92PX4DJ8. More information can be found on our lab website https://yadavlab.com/taok1-research-day/. We look forward to sharing our research and the work of other researchers.

In observance of Rare Disease Day today (Feb. 28th) we have started a campaign to fund TAOK1 research in the Yadav Lab. Please check out the link below to learn more and donate if you would like to support our research into TAOK1 and TAOK1-related Syndrome. Link: https://together.uw.edu/Campaign/taok1 .

TAOK1 Neurodevelopment Research Fund Support the TAOK1 Neurodevelopment Research Fund today.

For all those that wish to attend please register here: https://forms.gle/LPRSrwXxT4CP5vNr6 . Your registration will help us accommodate anyone who would like to attend and provide language interpretation if needed.

Save the date March 21st! We are excited to announce the 1st annual TAOK1 Rare Disease Day Virtual Symposium! This symposium will bring together families and researchers to discuss current TAOK1 research, therapeutic avenues and how to support TAOK1 research. We will be posting more details here and on our lab website https://yadavlab.com/ .

We are excited to share our newest preprint paper on BioRxiv on TAOK2 in 16p11.2 CNV cell lines and its effect on cilia length! The work for this paper was performed by a previous post doctoral scholar in the lab and our most senior graduate student, with the help of our collaborators at UCSF and other lab members.

TAOK2 Drives Opposing Cilia Length Deficits in 16p11.2 Deletion and Duplication Carriers Copy number variation (CNV) in the 16p11.2 (BP4-BP5) genomic locus is strongly associated with autism. Carriers of 16p11.2 deletion and duplication exhibit several common behavioral and social impairments, yet, show opposing brain structural changes and body mass index. To determine cellular mechani...

We are always excited to share the hard work of students in our lab. Check out this review on TAO kinases by one of our graduate students, which is now published!

Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders The roles of TAOKs in neurophysiology and neuropathology are explored.

Check out our most recent paper on TAOK1!

Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase Loss of kinase function in TAOK1 impairs autoregulation of its interaction with the plasma membrane.

Hello! We are the Yadav Lab at the University of Washington in the Pharmacology Department. The Yadav lab is interested in investigating the kinase signaling pathways that are important for neuronal development as well as in understanding how their dysfunction leads to neurodevelopmental and psychiatric disorders such as autism and schizophrenia. Our lab utilizes a combination of powerful approaches in chemical genetics, induced pluripotent stem cell (iPSC) technology, high-resolution live cell imaging, and quantitative proteomics to investigate the role of kinases and their downstream targets in neuronal development and disease. We are passionate about making scientific research inclusive and accessible.