Change HD

evelopment and is present throughout the lifespan. With gene knockdown therapy showing promise for treatment of HD, it is essential to understand how removing or disabling the gene could impact brain development. To look at brain structure, we use a special research Magnetic Resonance Imaging (MRI) to take images that we can analyze to measure the size and shape of different parts of the brain. To get an idea of brain function, we administer assessments that measure attention, reasoning, memory, movement, coordination and balance. We also use questionnaires that ask about moods, relationships, hobbies and talents. A testing day takes about 6 to 8 hours, or about as long as a school or work day. Participants are compensated for their time and effort.