Vydiant

Dietary patterns offer a perspective different from the traditional single nutrient intake analysis and may be used to formulate more comprehensive dietary recommendations for health and disease prevention or treatment. Our team, led by Jacqueline Monteiro, found dietary patterns affecting zinc and PUFA levels and identified serum linoleic/dihomo-γ-linolenic ratio (LA/DGLA) as a potential biomarker of zinc status: https://lnkd.in/gT_rMVr.

Our latest publication from the micronutrient intervention study in Brazilian children and teens (https://lnkd.in/eBdHA93). This new report identified and used polygenic risk scores for plasma vitamin B12 levels to stratify individuals into low, mild, and high risk for B12 insufficiencies. See: https://lnkd.in/eJwr64f

Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents Polymorphisms in genes related to the metabolism of vitamin B12 haven’t been examined in a Brazilian population. To (a) determine the correlation between the local genetic ancestry components and vitamin B12 levels using ninety B12-related genes; (b) determine associations between these genes and ...

Providing guidance to individuals to maintain health or reduce symptoms of chronic diseases is challenging because much of evidence base comes from evaluating differences between groups of people (e.g., case-control studies). A new approach is based on N-of-1 designs based on real world patient digital data. A recent review by some of the leaders of this effort is found here:

Creating Evidence from Real World Patient Digital Data Blog post about Frontiers research topic 'Creating Evidence from Real World Patient Digital Data'. Written by Jane Nikles, Eric J. Daza, Suzanne McDonald, Eric Hekler and Nicholas Schork

Vydiant has updated their website to better reflect our activities and missions. Check it out: vydiant.com

Many of us consumers are confused about the conflicting trends in nutritional advice: low fat, high protein, low carbohydrate, vegan, no multivitamins, yes multivitamins, and who knows what to make of ~80,000 dietary supplements (https://tinyurl.com/y2fe5pqu) currently on the U.S. market. This confusion results in part from research strategies and methods that do not account for the complexity of naturally-occurring chemicals in foods, the intricacies of genetic variability, and the impact of social determinants of health.

Although everyone involved in biomedical research is responsible for the current situation, journals have a special responsibility as gatekeepers for approving and disseminating study results. The American Journal of Clinical Nutrition (https://tinyurl.com/y2vvyo4o) is sharpening its focus by introducing 4 new sections: (i) great debates in nutrition to address major controversies, (ii) nutrigenomics and precision nutrition, both systems sciences, to better translate results to individuals, (iii) food systems and the environment to provide evidence to sustain nutrition as the climate changes accelerate, and (iv) women’s nutrition beyond pregnancy and lactation that acknowledges differences in physiology between males and females.

The AJCN plans are remarkably similar to the more granular suggestions for propelling the shift from reductionism to systems nutrition published in Genes&Nutrition in 2017 (https://tinyurl.com/y2lepum3). Editors at both journals recognized, as does the constructive criticism of others (https://tinyurl.com/y3ahh72t), that the status quo must change to produce more reliable evidence for individual and public health.