Cold Spring Harbor Laboratory Press

Nancy Wexler has spent a lifetime advancing our understanding of Huntington’s disease. In this moving New York Times profile, she reflects on the personal and scientific journey behind her new memoir, "My Life, My Science: Pursuing a Cure for Huntington’s Disease", published by Cold Spring Harbor Laboratory Press.

Read the article (free access):

The Researcher Who Didn’t Want to Know (Gift Article) Her decades of work on Huntington’s disease helped lead to the creation of a genetic test for the devastating condition. Why didn’t she take it herself?

Nearly all protein-coding and long noncoding genes transcribed by RNA polymerase II rely on cleavage and polyadenylation (CPA) for proper RNA maturation. More than 70% of human mRNA genes use alternative polyadenylation (APA), generating RNA isoforms with distinct functions and regulatory properties.

This review from the explores approaches to modulate poly(A) site usage, highlighting their value as research tools for studying APA and their emerging potential as therapeutic strategies for human disease.

Read the review: bit.ly/4sthgOt

Machine learning is transforming RNA secondary structure prediction.

This review in the explores how deep learning and other AI approaches are reshaping RNA structure prediction—while also highlighting the challenges researchers still face when predicting unfamiliar RNA structures.

The article also looks ahead to future hurdles, including modeling more complex and dynamic RNA structures. Read more: bit.ly/4spSj6s

What’s next for RNA biology at system scale? In this editorial, the editors frame a shift toward quantitative, integrative approaches, highlighting advances in measuring, modeling, and ultimately manipulating RNA across biological systems. http://bit.ly/41hv9UJ