JAMA

In this podcast, JAMA Deputy Editors Linda Brubaker, MD, and Preeti Malani, MD, MSJ, discussed the latest science published in JAMA:

➡️ Physical Activity and Outcomes,
➡️ Adverse Effects in Treatment
➡️ -Led Payer Integration Systems, and more

🎧 Listen now: https://ja.ma/4fhUczm

💬 Perspective by Attila J. Hertelendy, PhD, Lawrence O. Gostin, JD, and Gregory R. Ciottone, MD: The recent outbreak aboard the MV Hondius resulted in 10 cases and 3 deaths across multiple countries, with the causative Orthohantavirus andesense, which is endemic to Patagonia and capable of limited person-to-person transmission.

Although the outbreak remained bounded, delayed detection, fragmented operational authority, and inconsistent public health implementation revealed ongoing gaps in global pandemic preparedness, particularly in cross-jurisdiction coordination and point-of-entry capacities.

https://ja.ma/3PKRXdt

💬 Viewpoint by Leemore Dafny, PhD: The Break Up Big Medicine Act (BUBMA), recently introduced in Congress, proposes prohibiting vertical integration across the health care supply chain, including common ownership between medical service providers, insurers, pharmacy benefit managers, and wholesalers.

While BUBMA aims to address inherent conflicts of interest and competition concerns, it would force sweeping breakups of many organizations and may produce significant disruption.

https://ja.ma/4o50d4D

💬 Editorial by JAMA Deputy Editor Mary McDermott, MD, and Stephen Persell, MD, MPH: is prevalent in >116 million people in the US, with most requiring multiple medication classes for effective control. A network meta-analysis of antihypertensive drug classes found that angiotensin II receptor blockers (ARBs), alone or combined with calcium channel blockers (CCBs), were significantly less likely to be discontinued due to adverse events compared with placebo.

These findings support consideration of ARBs as initial therapy for patients without comorbidities requiring alternative medications, as improved adherence may reduce cardiovascular event rates.

https://ja.ma/3PNMimI