JAMA

https://ja.ma/4aNTZkp

"There were still patients to see, evaluations to finish, questions waiting for answers."

In , a psychiatric residency program director reflects on a resident’s missed shift, revealing the unseen emotional burdens carry and the importance of knowing someone notices.

https://ja.ma/44xdev0

📊 JAMA Guide to Statistics and Methods: Difference-in-differences is a common analytic strategy for estimating the impact of health care interventions or policies when randomization is not feasible.

By comparing pre-to-post changes between intervention and comparison groups, this method helps control for baseline differences and shared time trends, supporting causal inferences under the assumption of parallel trends.

Researchers should assess this assumption using contextual knowledge, preintervention data, and event studies, and tailor their statistical approach to account for clustered data and complex interventions.

https://ja.ma/4fmQsLi

📑 : affect more than 14.2 million people worldwide each year, with increased risk among older adults, particularly women and individuals with low bone mineral density.

Most hip fractures result from falls, and 1-year rates can be as high as 22%, with many patients experiencing lasting loss of and independence.

Management includes prompt repair, physical therapy, fall risk reduction strategies, and long-term use of or , such as bisphosphonates, denosumab, or parathyroid analogues, to prevent future fractures.

https://ja.ma/44yNIFx

💬 Perspective by John Hsiao, MD: diagnosis and treatment have advanced substantially since the unified conceptual framework published in 1976, with major progress in understanding -β and tau proteins as central drivers.

Monoclonal antibodies, including and , robustly clear brain amyloid-β and slow cognitive decline by approximately 30% in early disease, confirming a causal role for amyloid—though these effects remain modest and are limited by amyloid-related imaging abnormalities.

Current enable staging and preclinical diagnosis, and ongoing trials are testing whether early intervention can prevent onset.

https://ja.ma/4hgwNz3

Among selected adults with medically refractory, lung-limited stage IV non–small cell lung cancer (NSCLC) and respiratory failure, lung transplant following contemporary staging and dissemination-minimizing surgical technique was associated with higher early overall survival compared with medical management alone.

One-year survival post-transplant in these patients was also noninferior to that observed among transplant recipients without cancer.

These findings indicate that, for a rigorously defined subset of cases, lung transplant can extend early survival, but confirmation of long-term benefit and assessment of quality of life are needed.

https://ja.ma/4gGRN1H