JAMA Network Open

JAMA Network Open

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Validation of a 2-Gene Blood Test for Kawasaki Disease in Febrile Children 06/02/2026

A 2-gene qPCR assay measuring IFI27 and MCEMP1 accuracy distinguished from other pediatric illnesses with high sensitivity and stable performance across cohorts, supporting its adjunct role in early diagnosis.

Validation of a 2-Gene Blood Test for Kawasaki Disease in Febrile Children This diagnostic study validates a whole-blood quantitative polymerase chain reaction assay measuring IFI27 and MCEMP1 expression for distinguishing Kawasaki disease from other pediatric febrile illnesses.

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