Pone Rheumatology PLLC

Acute hepatitis and Human Adenovirus infection
WHO reports 920 from 33 countries of probable causes of acute hepatitis in children in context of human adenovirus viremia.
UK reported 260 cases of non-A-E hepatitis in children, 156 tested positive for human adenovirus and another 27 with available typing by partial hexon gene sequencing have had results consistent with human adenovirus 41.
It remains unclear whether human adenovirus infection - alone or in combination with what remains an unidentified additional cofactor- may result in development of hepatitis in children.
It is difficult to know whether hepatitis associated with human adenovirus is new or may have previously been below the threshold of recognition, or whether what we are observing simply represents two unrelated findings.
It is also possible that immunologic changes in a large cohort of young children may have occurred because of a lack of exposure to adenovirus and other common childhood viral illnesses during the coronavirus disease 2019 pandemic and, as a result, some children may have a dysregulated response to their first human adenovirus infection.
Pediatric gastroenterology, hepatology
University of Alabama at Birmingham
NEJM, 8/18/22

Paxlovid works as a treatment for COVID-19 but not as a preventive measure, particularly if you've been exposed to the coronavirus through a household member who is infected, according to a new announcement from Pfizer.
Medscape