Young-Pearse Lab
The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and developmental disorders of the nervous system, with the ultimate goal of identifying novel targets for therapeutic interventions for these diseases.
01/19/2026
We are excited to share our latest publication, " POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population" which was published in the journal Brain in December!
Lead author Courtney Benoit and Tracy discussed the paper on a recent podcast - the 33rd episode of "The Brain Podcast” – “Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment”.
https://open.spotify.com/episode/1sfNBP0JTiwC872EY6peGu?si=F2qKv3fLQCSSq0IKWt9SqQ&nd=1&dlsi=a13739d5e9de44ce
11/14/2025
Thank you to Jason Meyer and the team at Indiana University for including us in their 2nd Annual Indiana Stem Cell Research Symposium this week!
We are excited to share our latest publication , "Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" which was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week.
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02115