Dr. GPCR

How do chemokines and GPCRs decode selectivity? A landmark Cell paper delivers the answer—mapping how conserved and variable sequence–structure elements govern interaction logic across 46 chemokines and 23 GPCRs. The result: a framework for designing ligands with altered receptor preferences.

♦️ Defines “public” vs. “private” binding determinants

♦️ Highlights role of structured + unstructured regions

♦️ Includes a web tool + viral chemokine engineering demo

This is a must-read for GPCR modelers, immunopharmacologists, and ligand engineers.

➡️ Read the paperhttps://buff.ly/lca0KCU

GPCR pharmacology has evolved. Your training should too.

Enter Terry’s Corner—a new digital learning platform where 40+ years of drug discovery meets modern pharmacology. Led by Dr. Terry Kenakin, this series breaks down complex topics including:

• Agonism & efficacy through the lens of the operational model
• Binding kinetics using real-world dose-response curve analysis
• Allosteric modulation in the context of biased signaling and molecular dynamics

Designed for scientists building GPCR-targeted drugs—not just passing exams.

👉 Early Access starts July 1st, 2025 https://buff.ly/2c6dXnI