Clinimark

Virtual Summer School in Personalised Medicine.
June 14-18 2021
DON'T MISS IT!!!!

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EATRIS on LinkedIn: #EATRISPlus #personalisedmedicine #biomarkers We are very happy to announce the Summer School in , held virtually on June 14-18, 2021! Led by our partners INFARMED,...

Quantifying proteins based on peptide-coupled reporter ions is a multiplexed quantitative strategy in proteomics that alleviates the problem of ratio distortion caused by peptide cofragmentation, as commonly observed in other reporter-ion-based approaches, such as TMT and iTRAQ. Data-independent acquisition (DIA) is an attractive alternative to data-dependent acquisition (DDA) due to its better reproducibility.

To establish a new peptide-coupled reporter-ion-based tag that avoids ratio distortion in DDA and improves the throughput of DIA-based methods without sacrificing the data acquisition rate, researcher of the consortium propose a novel isobaric Ac-AG tag, which conceals quantitative information in isobarically labeled peptides and reveals it upon tandem MS in the form of peptide-coupled reporter ions. Read more about the results and discussions online https://pubs.acs.org/doi/10.1021/acs.analchem.0c03858

Visit our website https://clinimark.eu/ for more information on analytical and clinical validation of , and the COST Action network CliniMARK.

For more than a decade, it has been suggested that a complex interplay between and chronic inflammation represents one of the underlying mechanisms of gradual cardiac depression in (HF). Oxidative stress in HF is believed to be a consequence of increased circulating neurohormones and hemodynamic disorder, as well as inflammation and decreased oxygen delivery.

Having all that in mind, Researcher of the consortium conducted a pilot case-control study consisting of patients with HF due to coronary artery disease ( ) or idiopathic dilated cardiomyopathy ( ) in order to compare the distribution of common GST genotypes and the differential risk effect between these two entities.
Read all about this study online https://www.hindawi.com/journals/dm/2019/6984845/

Visit our website https://clinimark.eu/ for more information on analytical and clinical validation of , and the COST Action network CliniMARK.