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💊Drug Of The Day Levothyroxine💊

⭕️Trade names:
Eutirox, Levoxyl, Levothroid, Synthroid, Unithroid.

⭕️Classification:
It is a synthetic levoisomer of thyroxine (T4), similar to the endogenous hormone produced by the thyroid gland.

💢Indications:
Hypothyroidism: As replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis.

Pituitary TSH suppression in the treatment and prevention of euthyroid goiters (abnormal enlargement of the thyroid gland) and in the management of thyroid cancer.

💢Mechanism of action:
Thyroxine is de-iodinated to form triiodothyronine (T3) in the peripheral tissues. T3 enters the cell and binds to nuclear thyroid hormone receptors, and the hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration, thermogenesis, cellular growth and differentiation, and metabolism of proteins, carbohydrates and lipids. T4 and T3 also possess cardiac stimulatory effect.

💢Side effects:
General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating.

💢Central nervous system:
headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia.

💢Cardiovascular:
Palpitations, tachycardia, angina, cardiac arrest.

💢Dermatologic:
Allergic skin reactions, partial loss of hair in first few months of therapy in children.

💢Gastrointestinal:
diarrhea, vomiting, abdominal cramps and elevations in liver function tests.

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