The Le Grand Lab
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Understanding the molecular mechanisms by which stem cells undergo cell fate decisions, especially self-renewal, is one of the fundamental goals of modern regenerative medicine. Reconstruction of the adult skeletal muscle tissue relies on a pool of resident committed muscle stem cells called the satellite cells. Our research aim at (1) deciphering how extracellular signals regulate normal satellit
14/07/2016
Today we posted our latest manuscript on the pre-print server BiorXiv. This is the PhD work of Floriane Lacour, with great help from our lab engineer Elsa Vezin. Please share, discuss, and most of all wish us luck for getting published in a peer-reviewed journal soon. Any input on our work, through comments on the BioRxiv website, this page, our emails will be strongly appreciated.
R-spondin1 regulates muscle progenitor cell fusion through control of antagonist Wnt signaling... Tissue regeneration requires the selective activation and repression of specific signaling pathways in stem cells. As such, the Wnt signaling pathways have been shown to control stem cell fate. In many cell types, the R-Spondin (Rspo) family of secreted proteins acts as potent activators of the cano...
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