EpiGeneSys FP7

Modelling Approaches in Epigenetics 2014 workshop with
http://www.epigenesys.eu/en/activities/upcoming-epigenesys-activities/icalrepeat.detail/2014/03/20/274/-/modelling-approaches-in-epigenetics-2014-an-epigenesys-and-blueprint-joint-workshop

It will take place in Cambridge the 20th and 21th of march.

Modelling Approaches in Epigenetics 2014 - An EpiGeneSys and BLUEPRINT joint workshop | Epigenesys An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

Tomorrow, don't forget the 1st Who am I? workshop about epigenetics and evolution in Paris Diderot UNiversity.
http://www.labex-whoami.fr/en/news/280-epigenetics-and-evolution-who-am-i-workshop

News The first Who am I? workshop - epigenetics and evolution: four different perspectives - will be held on January 22, 2014 from 10.30am to 4pm.

Happy new year to all!

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA
http://www.sciencedirect.com/science/article/pii/S0092867413010234
A cell paper published by S. Adam, S.E. Polo and G. Almouzni in 2013 (Cell 155, 94–106. Doi :10.1016/j.cell.2013.08.029)

How transcription restarts in chromatin regions that have been silenced in response to DNA damage remains poorly understood. Here, they show in human cells that the histone chaperone HIRA deposits newly synthesized H3.3 histones at sites of UVC irradiation in a manner coupled to early ubiquitylation events associated with DNA damage detection. This early and transient function of HIRA is required for transcription reactivation once repair is complete and thus, they propose that HIRA-mediated histone deposition can act as a chromatin bookmarking system for transcription recovery after genotoxic stress.

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone... S. Adam, S.E. Polo and G. Almouzni (Cell, 2013, 155, 94–106. Doi :10.1016/j.cell.2013.08.029)