Immuno ICS

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Dysregulated miR-155 and miR-125b Are Related to Impaired B-cell Responses in Down Syndrome Children with Down Syndrome (DS) suffer from immune deficiency with a severe reduction in switched memory B cells and poor response to vaccination. Chromosome 21 encodes two microRNAs (miRs), miR-125b and miR-155, that regulate B-cell responses. We investigated the expression of miR-125b and miR-155...

JCI Insight - Antigen-mediated regulation in monoclonal gammopathies and myeloma Address correspondence to: Madhav V. Dhodapkar, HSRB E330 Emory University, 1760 Haygood Drive, Atlanta, Georgia 30322, USA. Phone:404.727.8372; Email: [email protected].