ARZT

*Recent Medical News and Updates (Continued)*
*FDA Grants Accelerated Approval to Bizengri (zenocutuzumab-zbco)*
- Approved for NRG1+ pancreatic adenocarcinoma and NRG1+ non–small cell lung cancer.

*FDA Approves Yesintek (ustekinumab-kfce)*
- Approved as a biosimilar to Stelara.

*FDA Approves Rapiblyk (landiolol)*
- Approved for atrial fibrillation and atrial flutter in critical care settings.

*FDA Approves Imkeldi (imatinib)*
- Approved for the treatment of certain forms of leukemia and other cancers.

*Recent Drug Applications*

*Govorestat*
- Applied Therapeutics received a complete response letter from the FDA for classic galactosemia treatment.

*STS101*
- Satsuma Pharmaceuticals' resubmission accepted by the FDA for acute migraine treatment.

*DCCR (Diazoxide Choline)*
- Soleno Therapeutics' review period extended by the FDA for Prader-Willi syndrome.

*Plozasiran*
- Arrowhead Pharmaceuticals submitted a new drug application for familial chylomicronemia syndrome treatment.

*Reproxalap*
- Aldeyra Therapeutics' new drug application accepted for dry eye disease treatment.

*Tamibarotene*
- Syros Pharmaceuticals announced topline data from a Phase 3 trial for higher-risk myelodysplastic syndrome.

*Sacituzumab Tirumotecan (sac-TMT)*
- Granted Breakthrough Therapy Designation for specific non-small cell lung cancer patients.

*LP-184*
- Lantern Pharma's investigational drug received the second fast track designation for triple-negative breast cancer.

*Anaphylm (epinephrine)*
- Aquestive Therapeutics received positive FDA feedback for sublingual film for anaphylaxis treatment.

⛔️DRUG-DRUG Interaction: ⛔️

1. PDE-5 INHIBITORS AND NITRATES :

• PDE-5 Inhibitors (Sildenafil, Tadalafil) are used for erectile dysfunction.
• Nitrates (Nitroglycerin) is used as an anti-anginal.
SO Both medications cause blood vessels to dilate, which can cause severe hypotension .

2. NSAID’S AND WARFARIN :

• NSAID's increase the risk of bleeding .
• Warfarin: is an anti-coagulant that increases the risk of bleeding too.
SO Together, they REALLY increase the risk of bleeding!

3. SPIRNOLACTONE AND POTASSIUM CHLORIDE :

• Spironolactone (Potassium-sparing diuretic) holds onto potassium in the body If taken with a potassium supplement, the patient can experience severe hyperkalemia and dysrhythmias!

4. LITHIUM AND DIURETICS :

• Lithium (Mood stabilizer): is a cation similar to sodium and acts similar to sodium!
• Diuretics: get rid of fluids and can also get rid of sodium (which is a salt)
So If salt is giving with diuretics, lithium will take the place of "missing sodium" in our body and reach toxic
levels!

5. LANOXIN (DIGOXIN) AND AMIODARONE :

• Digoxin :is a cardiac glycoside that improves the force of contraction to make meaningful beats
• Amiodarone: is an anti-arrhythmic and may affect how much digoxin is absorbed in the bloodstream Together, this may cause digoxin toxicity!

6. ATORVASTATIN AND AMIODARONE :

• Amiodarone (Anti-arrhythmic) : is used to irregular heartbeats like A-fib
• Atorvastatin (Statins): is given to reduce cholesterol levels
Amiodarone will increase the level or effect of Atorvastatin by P-glycoprotein (MDR1) efflux transporter.

7. MAOI'S AND OTHER ANTIDEPRESSANTS :

Stop MAOIs for at least 2 weeks before taking other antidepressants. It can cause
serotonin syndrome which has UPPER-type symptoms (agitation, muscle twitching, fever, seizures)

8. BENZODIAZEPINES AND OPIOIDS

• Alprazolam and Percocet (Oxycodone Acetaminophen) produce sedative effects