OneDrug

New Biomarker Test Helps Identify Hidden CYP2D6 Poor Metabolizers, Reducing Need for Broad Genotyping

BPS Publications Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of 20–25% of commonly used clinical drugs. Between 5 and 10% of Caucasians are homozygous carriers of variant alleles encoding no CYP2D6 enz...

CPIC Leads Global Pharmacogenomics Adoption with 10K+ Citations, 1.4M Views, and Growing EHR Integration

Advancing Clinical Pharmacogenomics Worldwide Through the Clinical Pharmacogenetics Implementation Consortium (CPIC) The Clinical Pharmacogenetics Implementation Consortium (CPIC) has advanced clinical pharmacogenomics since 2009 by developing freely available, evidence-based gene/drug guidelines. Covering 34 genes...

ABCC4 Gene Variant Found to Indirectly Lower 5′-DFUR AUC in Capecitabine Treatment via TP Upregulation

BPS Publications Aims Capecitabine converts to 5-fluorouracil (5-FU) in 3 steps. We previous demonstrated a significant association between area under the plasma concentration–time curve (AUC) of a metabolite 5′-deo...