Therapeutic Interventions for Psychosis Research Lab - TIP Lab

This week’s summary highlights how artificial intelligence is being used to predict clinical outcomes in psychotic disorders. Across 30 studies, researchers tested AI learning models using information such as symptoms, cognition, brain scans, and treatment history. Prediction accuracy ranged widely, but key factors like gender, income, relapse history, medication use, and brain changes played important roles. Overall, the review shows that AI holds real promise for improving mental-health care, but more work is needed before these models can reliably support clinical decisions.

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This week’s research summary reviews the effectiveness of Cognitive Behavioural Therapy (CBT) for sleep problems in people with or at risk of psychosis.
This systematic review of 14 studies found that CBT shows strong potential and significantly improved sleep in this population. Interestingly, therapists often adapted the therapy, avoiding techniques like sleep restriction (which could worsen symptoms like paranoia) and instead using gentler strategies, such as setting regular routines.
Participants didn’t just sleep better but also reported improved mood, reduced anxiety, and better daily functioning.

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This week’s summary covers a five-year study of over 3,500 adolescents, exploring the link between sleep disruptions and psychosis vulnerability. The study found that poor sleep consistently predicted an increase in psychotic-like experiences (PLEs) over time. The research identified a specific cognitive pathway: poor sleep was linked to difficulties with response inhibition (the ability to suppress an impulse), which in turn explained the rise in PLEs.
These findings highlight poor sleep and impaired inhibition as key early indicators of psychosis risk, suggesting valuable targets for prevention.

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Today’s research summary examines the profound impact of Adverse Childhood Experiences (ACEs) on patients with schizophrenia.
Researchers found that 93% of people with schizophrenia surveyed reported experiencing at least one ACE, with parental separation or death being the most common. The findings revealed a clear positive correlation where more ACEs are associated with more severe symptoms were. Specific experiences like family incarceration were also linked to symptom severity, while physical abuse was associated with hospital admissions.
This research underscores the critical need for early intervention and support for children exposed to trauma, given its potential role in the development of schizophrenia.

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