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12/13/2020
Nobel Lecture: Emmanuelle Charpentier, Nobel Prize in Chemistry 2020 Emmanuelle Charpentier delivered her Nobel Lecture on 8 December 2020. She was introduced by Professor Claes Gustafsson, Chairman of the Nobel Committee for ...
10/07/2020
I am excited to start a new online class, Foundations of Instructional Design at the University of Toronto. I'm looking forward to composing a learning needs analysis and learning effective instructional solutions.
08/27/2020
“The initiation of the Phase 2/3 trial is a major step forward in our progress toward providing a potential vaccine to help fight the ongoing COVID-19 pandemic, and we look forward to generating additional data as the program progresses.”
What's a pivotal clinical trial?
A pivotal clinical trial is a clinical study seeking to demonstrate the efficacy of a new drug in order to obtain its marketing approval by regulatory authorities. These studies have appropriate endpoints, a well-defined patient population, and a large number of patients.
Pfizer and BioNTech Choose Lead mRNA Vaccine Candidate Against COVID-19 and Commence Pivotal Phase 2/3 Global Study | Pfizer Companies advance nucleoside-modified messenger RNA (modRNA) candidate BNT162b2, which encodes an optimized SARS-CoV-2 full-length spike glycoprotein, at a 30 µg dose level in a 2 dose regimen into Phase 2/3 Study Candidate and dose level selection informed by preclinical and clinical data obtained...
05/08/2020
Looking beyond SARS CoV-2; drugs targeting the main protease may prove useful against future coronaviruses. This type of “biological scissor” cuts polypeptide chains translated from viral RNA, a step required to form functional viral proteins.
“When the genetic sequences of the various SARS-CoV-2 viral proteins became available, they revealed remarkable similarities between its main protease and those of two coronaviruses responsible for earlier outbreaks”.
“This realization planted a seed of hope. If a drug could block that protein, it stood a good chance of working against not just this coronavirus but whatever one emerged next”.
How big pharma firms are quietly collaborating on new coronavirus antivirals Behind the scenes, companies including Novartis, Takeda, and Gilead are collaborating in a loose alliance. Their work might not be done in time to stop COVID-19, but they hope it can prevent the next pandemic
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