PLN Genetic Mutation Awareness

As we welcome the new year, we reflect on the progress made and the work still ahead. Here’s to continued awareness, research, and community in the year to come.

What are your New Year’s resolutions for 2026?

PLN R14Del is a rare genetic heart condition, but its impact is anything but small. One mutation can affect how heart muscle cells handle calcium, setting off changes that influence heart structure, rhythm, and long-term function.

What makes PLN especially challenging is its variability. Some carriers feel well for years, while others develop arrhythmias or cardiomyopathy early. Two people in the same family, carrying the same mutation, can have completely different journeys.

This unpredictability is why genetic testing, regular cardiac monitoring, and research matter so much. Understanding PLN earlier allows for surveillance, prevention, and life-saving intervention; before symptoms become severe.

At the PLN Foundation, we’re committed to education, connection, and accelerating research so genetics don’t dictate outcomes in silence.

Knowledge changes trajectories