Biotech

FDA, CDC support resuming use of J&J vaccine after advisory panel vote 🦠💉🧪

A group of advisers to the Centers for Disease Control and Prevention said vaccinations with Johnson & Johnson's coronavirus shot should be resumed in the U.S., deciding in a Friday meeting that updated labeling would be sufficient to alert healthcare providers and the public to the risk of a rare but serious side effect.

The advisers voted 10-4 in favor of the recommendation, clearing the way for the CDC and Food and Drug Administration to lift their recommended pause on vaccinations just two hours later.

Would you take the J&J shot?

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📰 Source: CDC ()

First monkey–human embryos reignite debate over hybrid animals 🐒🧪👶

Scientists have successfully grown monkey embryos containing human cells for the first time — the latest milestone in a rapidly advancing field that has drawn ethical questions.

In the work, published on 15 April in Cell () the team injected monkey embryos with human stem cells and watched them develop. They observed human and monkey cells divide and grow together in a dish, with at least 3 embryos surviving to 19 days after fertilization. “The overall message is that every embryo contained human cells that proliferate and differentiate to a different extent,” says Juan Carlos Izpisua Belmonte, a developmental biologist at the Salk Institute for Biological Studies in La Jolla, California, and one of the researchers who led the work.

Researchers hope that some human–animal hybrids — known as chimaeras — could provide better models in which to test drugs, and be used to grow human organs for transplants. Members of this research team were the first to show in 20192 that they could grow monkey embryos in a dish for up to 20 days after fertilization. In 2017, they reported a series of other hybrids: pig embryos grown with human cells, cow embryos grown with human cells, and rat embryos grown with mouse cells.

What do you think about hybrid animals?

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✍️ Astrobiotechnology ()
🖼️ NPR ()

🗃️ Source: Cell ()
🔸 Tan et al (April, 2021) , “Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo”

Myelin Loss Shown To Play A Significant Role in Age-Related Brain Deterioration 🧠💊🧬

A team of scientists at the University of Portsmouth has identified myelin loss to be one of the significant factors of age-related brain deterioration.

The study, published in Aging Cell, shows that there is increasing evidence that myelin disruption is an important factor that contributes to the age-related loss of brain plasticity and repair responses. The loss of myelin is shown to be the cause of cognitive decline and is central to several neurodegenerative diseases, such as Multiple Sclerosis and Alzheimer’s disease.

The study found that the cells which are responsible for replenishing lost myelin, become less efficient with age and identified a key gene that is most affected by aging, which in turn reduces the cells' ability to restore lost myelin.

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✍️ Siddhant Kamat(
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🔸 Rivera et. al (March, 2021) , “Article Title” by Journalist ()

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🎓 Siddhant Kamat is a biotechnology graduate from the University of Mumbai and a member of our Internship Program.
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