DERMA PRO

Glutathione

(GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides.
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It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine (which is attached by normal peptide linkage to a glycine).

Function

Glutathione has multiple functions:
Glutathione has recently been used as an inhibitor of melanin in the cosmetics industry. In countries such as Japan and the Philippines, this product is sold as a skin-whitening soap. Glutathione competitively inhibits melanin synthesis in the reaction of tyrosinase and L-DOPA by interrupting L-DOPA's ability to bind to tyrosinase during melanin synthesis. The inhibition of melanin synthesis was reversed by increasing the concentration of L-DOPA, but not by increasing tyrosinase. Although the synthesized melanin was aggregated within one hour, the aggregation was inhibited by the addition of glutathione.
These results indicate glutathione inhibits the synthesis and agglutination of melanin by interrupting the function of L-DOPA.

Dry and oily skin

Formation of pimple and acne

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