Organics MDPI

📘 Organics – Volume 5, Issue 4 (December 2024)

We’re excited to share another issue of Organics for 2024 — Volume 5, Issue 4 (December 2024) — featuring 17 high-quality research articles advancing the field of organic chemistry.

⭐ We warmly invite you to explore the latest insights and discoveries shaping the future of organic research.

Cover Story: l-(+)-Furanomycin, a crucial substrate for isoleucyl aminoacyl-tRNA synthetase, replaces isoleucine during protein translation and exhibits antibacterial properties in vitro. Various synthetic approaches have been developed to produce l-(+)-Furanomycin and its analogs. This review focuses on total synthesis strategies and the biological significance of Furanomycin, a distinctive antibacterial agent with a non-proteinogenic amino acid core. It covers its isolation and diverse synthetic methodologies, including those using chiral substrates like carbohydrates and amino acids and alternative approaches with achiral starting materials like furans and cyclopentadiene. Methods relying on amino acids are particularly appealing, involving only six to seven steps for a swift and flexible process to access Furanomycin and its analogs.

🔗 Access all articles in this issue (free access):
https://brnw.ch/21x0BKx

📘 Organics – Volume 5, Issue 3 (September 2024)

We’re excited to share another issue of Organics for 2024 — Volume 5, Issue 3 (September 2024) — featuring 10 high-quality research articles advancing the field of organic chemistry.

⭐ We warmly invite you to explore the latest insights and discoveries shaping the future of organic research.

Cover Story: We have successfully synthesized a new set of indanone and indanol building blocks that show promise in the context of drug discovery. The research relied on highly chemoselective reactions of a readily accessible but densely functionalized molecule. In particular, the noted keto acid was identified as the versatile springboard that permitted the synthesis of the remaining indan-based building blocks. By unlocking these new synthetic pathways, we have expanded the repertoire of indan-based structures, which may, in turn, facilitate the discovery of future drug candidates.

🔗 Access all articles in this issue (free access):
https://brnw.ch/21x0BK2

📝 Recent Advances in Asymmetric Transfer Hydrogenation, edited by Prof. Dr. Zbigniew Czarnocki and Dr. Zuzanna Molęda
📬 Welcome your submission: https://brnw.ch/21x0vzi
📆Deadline: 30 September 2026

📘 Organics – Volume 5, Issue 2 (June 2024)

We’re excited to share another issue of Organics for 2024 — Volume 5, Issue 2 (June 2024) — featuring 6 high-quality research articles advancing the field of organic chemistry.

⭐ We warmly invite you to explore the latest insights and discoveries shaping the future of organic research.

Cover Story: Polyether amines are versatile compounds characterized by a flexible structure of polyoxypropylene and polyoxyethylene backbones with amine groups at each end. This study demonstrates the innovative use of polyether amine as a recyclable catalyst for the aerobic oxidation of thiophenols, leading to the synthesis of disulfides. In contrast to known methods for thiol oxidation, this polyether amine-based catalytic process eliminates the need for expensive stoichiometric oxidants and minimizes the formation of over-oxidized by-products. A remarkable yield of over 96% was achieved for all 16 test substrates, encompassing a diverse range of functional groups under catalytic aerobic oxidation conditions, using just 0.5% of polyether amine as the catalyst.

📖 Read the cover article for free:
https://brnw.ch/21wZYIN

🔗 Access all articles in this issue (free access):
https://brnw.ch/21wZYIO